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Scleroderma (sklair-oh-DUR-muh), also known as systemic sclerosis, is a group of rare diseases that involve the hardening and tightening of the skin. Symptoms of colon cancer can include: A change in bowel habits, such as more frequent diarrhea or constipation. 48:56. Case Report A 41-year-old man with a past medical history of type-2 dia-betes, hypertension, gastroesophageal reflux disease, depres-sion, and posttraumatic stress disorder presented for a 2-month history of severe, diffuse joint pain, and 50-pound Stercoral perforation of the colon is a rare complication of constipation, and there have only been a few reported cases of stercoral perforation of the colon secondary to opioid-induced constipation. tightness in the chest. diarrhea. Facial Nerve Damage. The recommended Creon dosage for newborns and infants ages 12 months and younger is 3,000 lipase units for every 120 mL (about 4 ounces) of formula consumed or for each episode of breastfeeding. online. 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